Talk:Conditions comorbid to autism

This is the talk page for discussing improvements to the Conditions comorbid to autism article.
This is not a forum for general discussion of the article's subject.

Put new text under old text. Click here to start a new topic.
New to Wikipedia? Welcome! Learn to edit; get help.

Article policies

Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL

Archives: 1: 2 months

Disability

Conditions comorbid to autism is within the scope of WikiProject Disability. For more information, visit the project page, where you can join the project and/or contribute to the discussion.DisabilityWikipedia:WikiProject DisabilityTemplate:WikiProject DisabilityDisability

Medicine: Neurology Low‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine
Low	This article has been rated as Low-importance on the project's importance scale.
	This article is supported by the Neurology task force.

Autism Mid‑importance

	This article is within the scope of WikiProject Autism, a collaborative effort to improve the coverage of all aspects of autism and autistic culture on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.AutismWikipedia:WikiProject AutismTemplate:WikiProject AutismAutism
Mid	This article has been rated as Mid-importance on the project's importance scale.

Sociology

	Society portal This article is within the scope of WikiProject Sociology, a collaborative effort to improve the coverage of sociology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.SociologyWikipedia:WikiProject SociologyTemplate:WikiProject Sociologysociology
???	This article has not yet received a rating on the project's importance scale.

Psychology

	Psychology portal This article is within the scope of WikiProject Psychology, a collaborative effort to improve the coverage of Psychology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PsychologyWikipedia:WikiProject PsychologyTemplate:WikiProject Psychologypsychology
???	This article has not yet received a rating on the project's importance scale.

Article name change, please

Because the name of the article is "Conditions comorbid to autism spectrum disorders", it implies that autism is a morbidity, i.e., a disease, which it is not. I am therefore asking that the name of this article be changed to "Conditions co-occurring with autism spectrum disorders" to better reflect reality and cause less offense. 80.193.98.150 (talk) 11:55, 2 December 2023 (UTC)[reply]

Hi you! "Conditions comorbid to autism" refer to the medical use of the word autism, not to the word as describing neurodiversity. Therefore, comorbid is correct.Lova Falk (talk) 07:38, 7 March 2025 (UTC)[reply]

Transferring section: Reduced NMDA‐receptor function

I removed this section on Reduced NMDA receptor function. It does not fit well in the article about comorbid conditions with ASD, because it does not describe a distinct medical or psychiatric condition that co-occurs with autism. Instead, it discusses a potential neurobiological mechanism underlying ASD itself. The text describes how NMDA receptor dysfunction may contribute to autism symptoms, but it does not identify a separate, diagnosable disorder that occurs alongside ASD. The section belongs in an article about the neurobiology of autism, rather than one on comorbid conditions. This section would fit better in a neurobiological section, something like a section or article about the neurochemical basis of autism, or pathophysiology of autism, where different neurotransmitter and receptor abnormalities are discussed in relation to autism. I don't know if this exists right now at WP.

Anyway, below is the original text in case a better place for it can be found.

===Reduced NMDA‐receptor function=== Reduced NMDA receptor function has been linked to reduced social interactions, [[hyperlocomotion|locomotor hyperactivity]], self-injury, [[prepulse inhibition]] (PPI) deficits, and sensory hypersensitivity, among others. Results suggest that NMDA dysregulation could contribute to core ASD symptoms.<ref>{{cite journal | vauthors = Gandal MJ, Anderson RL, Billingslea EN, Carlson GC, Roberts TP, Siegel SJ | title = Mice with reduced NMDA receptor expression: more consistent with autism than schizophrenia? | journal = Genes, Brain and Behavior | volume = 11 | issue = 6 | pages = 740–750 | date = August 2012 | pmid = 22726567 | pmc = 3808979 | doi = 10.1111/j.1601-183X.2012.00816.x }}</ref>

Lova Falk (talk) 07:36, 7 March 2025 (UTC)[reply]

I now pasted the section here: Mechanism_of_autism#Reduced_NMDA‐receptor_function Lova Falk (talk) 07:44, 7 March 2025 (UTC)[reply]

Transferring section: Abnormal folate metabolism

Also this section cut out of this article and will be added to Mechanism_of_autism. The reason is that while some individuals with autism exhibit folate metabolism abnormalities, this association does not necessarily classify CFD as a comorbid condition of autism. The way it is described "many children with ASD and cerebral folate deficiency have marked improvements in their clinical status when taking folinic acid", it is rather a cause of autism, or a subgroup within the group of people with autism, than a comorbidity. Lova Falk (talk) 11:16, 7 March 2025 (UTC)[reply]

PS I will give this page a rest now and see what you all will do with those edits that I made. Later I'll come back and scrutinise this page some more. Lova Falk (talk) 11:22, 7 March 2025 (UTC)[reply]

Removing section: Brain fog

This section says brain fog is... and then: "Brain fog can be present in patients with autism spectrum disorder (ASD). Its prevalence, however, remains unknown.[31]" I checked source 31. In the introduction it says: " Brain “fog” characterizes patients with many neuroimmune diseases [...] as well as those with autism spectrum disorders (ASDs) and “minimal cognitive impairment,” which is now considered the early clinical presentation of Alzheimer's disease (AD) (Drzezga et al., 2011)." The link is to an article about Alzheimer's, not ASD. In the same article is the sentence: "Children with ASDs are also characterized by brain “fog” (Rossignol and Frye, 2012)" If I look at the Rossignol and Frye article, the term brain fog or brain "fog" is nowhere to be found. Instead, the article discusses cognitive dysfunction in ASD, linking cognitive dysfunction to oxidative stress, mitochondrial dysfunction, and immune dysregulation. I am quite shocked that Drzezga's article was approved... So, no evidence for brain fog as a comorbid condition to ASD. Lova Falk (talk) 10:04, 10 March 2025 (UTC)[reply]

Transferring section:Abnormal redox metabolism

I will also move this section to Mechanism_of_autism. The evidence presented ties redox metabolism disturbances directly to metabolic, genetic, mitochondrial, and environmental factors involved in ASD, suggesting it is part of the underlying pathophysiology rather than a separate condition occurring alongside autism. Since redox imbalance is being framed as contributing to ASD symptoms through oxidative stress and mitochondrial dysfunction, it fits better in the Mechanisms of autism article rather than a comorbidity list, which is more appropriate for independent medical conditions commonly seen alongside ASD (like ADHD, epilepsy, etc.). Lova Falk (talk) 10:12, 10 March 2025 (UTC)[reply]

Once again, I'll give this article some time, and if nothing happens, I'll continue my scrutiny. It feels a bit lonely here though... Lova Falk (talk) 10:17, 10 March 2025 (UTC)[reply]